Fungicidal Power You Can Trust®
High-performance antifungal3,7
NAFTIN® (Naftifine HCl) Gel, 2% delivers the proven efficacy of an allylamine with the safety profile of vehicle3
- A fungicidal allylamine that attacks offending microorganisms—highest efficacy observed at 6 weeks (4 weeks post last treatment)3
- Adverse events comparable to vehicle3:
- Application site reactions were the most common adverse reactions seen in clinical trials with NAFTIN® Gel, 2% (2%) vs vehicle (1%)
Harnessing the power of a fungicidal allylamine in a 2% gel3
Clinically proven to clear interdigital tinea pedis even after treatment ends3
Primary endpoint
Complete cure at week 6 (4 weeks post last treatment) with NAFTIN® Gel, 2%3
Study 1
- Complete cure rates of 17% were achieved at 4 weeks post last treatment with NAFTIN® Gel vs 2% with vehicle3,a
- Treatment effectiveness rates of 54% were achieved at week 6
(4 weeks post last treatment) with NAFTIN® Gel vs 6% with vehicle3,b - Mycological cure rates of 65% were achieved at week 6 (4 weeks post last treatment) with NAFTIN® Gel, 2% vs 14% with vehicle3,c
Study 1
Effective against interdigital tinea pedis at week 6 (4 weeks post last treatment)3
COMPLETE CURE
TREATMENT EFFECTIVENESS
MYCOLOGICAL CURE
aComplete cure is a composite endpoint of both mycological cure and clinical cure.
Clinical cure is defined as the absence of erythema, pruritus, and scaling (grade of 0).3
bTreatment effectiveness is a negative KOH preparation and negative dermatophyte culture,
erythema, scaling, and pruritus grades of 0 or 1 (absent or nearly absent).3
cMycological cure is defined as negative KOH and dermatophyte culture.3
Study design: 2 randomized, double-blind, vehicle-controlled, multicenter, 6-week studies in 1175 subjects with interdigital tinea pedis; in study 1, NAFTIN® Gel, 2% (n=382) was compared with vehicle (n=179) at week 6 after a 2-week treatment for interdigital tinea pedis; and in study 2, NAFTIN® Gel, 2% (n=400) was compared with vehicle (n=213) at week 6 after a 2-week treatment for interdigital tinea pedis.3
Study 2
- Complete cure rates of 26% were achieved at week 6 (4 weeks post last treatment) with NAFTIN® Gel 2% vs 3% with vehicle3,a
- Treatment effectiveness rates of 51% were achieved at week 6
(4 weeks post last treatment) with NAFTIN® Gel, 2% vs 7% with vehicle3,b - Mycological cure rates of 59% were achieved at week 6 (4 weeks post last treatment) with NAFTIN® Gel, 2% vs 10% with vehicle3,c
Study 2
Effective against interdigital tinea pedis at week 6 (4 weeks post last treatment)3
COMPLETE CURE
TREATMENT EFFECTIVENESS
MYCOLOGICAL CURE
aComplete cure is a composite endpoint of both mycological cure and clinical cure.
Clinical cure is defined as the absence of erythema, pruritus, and scaling (grade of 0).3
bTreatment effectiveness is a negative KOH preparation and negative dermatophyte culture,
erythema, scaling, and pruritus grades of 0 or 1 (absent or nearly absent).3
cMycological cure is defined as negative KOH and dermatophyte culture.3
Study design: 2 randomized, double-blind, vehicle-controlled, multicenter, 6-week studies in 1175 subjects with interdigital tinea pedis; in study 1, NAFTIN® Gel, 2% (n=382) was compared with vehicle (n=179) at week 6 after a 2-week treatment for interdigital tinea pedis; and in study 2, NAFTIN® Gel, 2% (n=400) was compared with vehicle (n=213) at week 6 after a 2-week treatment for interdigital tinea pedis.3